Legionella and beyond (2000-)- Hubert Hilbi, Hiroki Nagai, Tomoko Kubori and Craig R. Roy, Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System. Current Topics in Microbiolog yand Immunology 413, 2018 in press, https://doi.org/10.1007/978-3-319-75241-9_9
Kubori T, Kitao-Ando T, Ando H, Nagai H. LotA, a Legionella deubiquitinase, has dual catalytic activity and contributes to intracellular growth. Cell. Microbiol. in press, DOI:10.1111/cmi.12840 Selected as an Editor's Choice
- C. Maita, M. Matsushita, M. Miyoshi, T.
Okubo, S. Nakamura, J. Matsuo, M. Takemura, M. Miyake, H. Nagai, H. Yamaguchi,
Amoebal endosymbiont Neochlamydia protects host amoebae against Legionella
pneumophila infection by preventing Legionella entry, Microbes and Infection
(2018), doi: 10.1016/j.micinf.2017.12.012.
- Kubori T, Nagai H. Isolation of the Dot/Icm
Type IV Secretion System Core Complex from Legionella pneumophila for Negative
Stain Electron Microscopy Studies. Bio-protocol Vol 7, Iss 8, April 20, 2017 DOI:
10.21769/BioProtoc.2229
- Kubori T, Bui XT, Hubber A and Nagai H (2017) Legionella RavZ Plays a Role in Preventing Ubiquitin Recruitment to Bacteria-Containing Vacuoles. Front. Cell. Infect. Microbiol. 7:384. doi: 10.3389/fcimb.2017.00384
- Hubber A, Kubori T, Coban C, Matsuzawa T, Ogawa M, Kawabata T, Yoshimori T, Nagai H. Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis. Sci Rep. 2017 Mar 20;7:44795. doi: 10.1038/srep44795.
- Maita C, Matushita M, Okubo T, Matsuo J, Miyake M, Nagai H, Yamaguchi H. Draft Genome Sequences of Legionella pneumophila JR32 and Lp01 Laboratory Strains Domesticated in Japan. Genome Announc 4, (2016). doi: 10.1128/genomeA.00791-16.
- Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa
K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama
I, Colonna M and Arase H. Microbially cleaved immunoglobulins are sensed by the
innate immune receptor LILRA2. Nat. Microbiol. 1, 16054 (2016). doi: 10.1038/nmicrobiol.2016.54
- Kubori T, *Nagai H. The Type IVB secretion system: an enigmatic chimera. Curr Opin Microbiol 29, 22-29 (2016). doi: 10.1016/j.mib.2015.10.001
- 永井宏樹、病原菌の侵入・増殖と宿主真核細胞の攻防、実験医学 (羊土社), 33, 2778-2783 (2015).
- Kuroda T, Kubori T, Thanh Bui X, Hyakutake A, Uchida Y, Imada K, *Nagai H. Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion. Sci Rep 5, 10912 (2015). doi: 10.1038/srep10912
- Kubori T, Hubber AM, *Nagai H. Hijacking the host proteasome for the temporal degradation of bacterial effectors. Methods Mol Biol 1197, 141-152 (2014). doi: 10.1007/978-1-4939-1261-2_8
- Nagai H. The host-pathogen interaction of Legionella pneumophila. Nihon Saikingaku Zasshi 69, 503-511 (2014).
- 永井宏樹、レジオネラ症とその病原メカニズムをめぐる新展開、呼吸器内科 (科学評論社), 26, 9-15 (2014).
- Kubori T, Koike M, Bui XT, Higaki S, Aizawa SI, *Nagai H. Native structure of a type IV secretion system core complex essential for Legionella pathogenesis. Proc Natl Acad Sci U S A 111, 11804-11809 (2014). doi: 10.1073/pnas.1404506111
- Hubber A, Arasaki K, Nakatsu F, Hardiman C, Lambright D, De Camilli P, Nagai H, Roy CR. The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple legionella effector proteins. PLoS Pathog 10, e1004222 (2014). doi: 10.1371/journal.ppat.1004222
- Ishida K, Sekizuka T, Hayashida K, Matsuo J, Takeuchi F, Kuroda M, Nakamura S, Yamazaki T, Yoshida M, Takahashi K, Nagai H, Sugimoto C, Yamaguchi H. Amoebal Endosymbiont Neochlamydia Genome Sequence Illuminates the Bacterial Role in the Defense of the Host Amoebae against Legionella pneumophila. PLoS One 9, e95166 (2014). doi: 10.1371/journal.pone.0095166
- Hubber A, Kubori T, *Nagai H. Modulation of the ubiquitination machinery by legionella. Curr Top Microbiol Immunol 376, 227-247 (2013). doi:10.1007/82_2013_343
- Hori JI, Pereira MS, Roy CR, *Nagai H, Zamboni DS. Identification and functional characterization of K(+) transporters encoded by Legionella pneumophila kup genes. Cell Microbiol 15, 2006-2019 (2013). doi:10.1111/cmi.12168
- Matsuo J, Nakamura S, Ito A, Yamazaki T, Ishida K, Hayashi Y, Yoshida M, Takahashi K, Sekizuka T, Takeuchi F, Kuroda M, Nagai H, Hayashida K, Sugimoto C, Yamaguchi H., Protochlamydia induces apoptosis of human HEp-2 cells through mitochondrial dysfunction mediated by chlamydial protease-like activity factor. PLoS ONE 8(2): e56005. doi:10.1371/journal.pone.0056005 (2013). doi:10.1371/journal.pone.0056005
- Nagai H, Kubori T. Purification and characterization of legionella u-box-type e3 ubiquitin ligase. Methods Mol Biol 954, 347-354 (2013). doi:10.1007/978-1-62703-161-5_21
- Tomoko Kubori and Hiroki Nagai. Bacterial
effector-involved temporal and spatial regulation by hijack of the host
ubiquitin pathway. Front. Microbiol., 2:145. Epub 2011 Jul 4 (2011). doi: 10.3389/fmicb.2011.00145
- Hiroki Nagai and Tomoko Kubori. Dot/Icm
type IVB secretion systems of Legionella
and other gram-negative bacteria. Front. Microbiol., 2:136. Epub
2011 Jun 2 (2011). doi: 10.3389/fmicb.2011.00136
- Tomoko Kubori, Naoaki Shinzawa, Hirotaka Kanuka and Hiroki
Nagai, Legionella metaeffector
exploits host proteasome to temporally regulate cognate effector. PLoS
Pathogens, 6, 12, e1001216 (2010). doi: 10.1371/journal.ppat.1001216
Covered as a research highlight in Nat. Rev. Microbiol. 9, 80-81 (February 2011) | doi:10.1038/nrmicro2509 - Noboru Nakano, Tomoko Kubori, Miki Kinoshita, Katsumi
Imada and Hiroki Nagai, Crystal Structure of Legionella DotD: insights into relationship between type IVB and
type II/III secretion systems. PLoS Pathogens 6, 10, e1001129
(2010). doi:10.1371/journal.ppat.1001129
Covered as a "100 selected papers" in Annual Report 2010-2011 of Osaka University - 永井宏樹、病原細菌のIV 型分泌系、日本細菌学雑誌(日本細菌学会)、65:379–386,(2010).
- 永井宏樹、レジオネラの宿主細胞内動態とエフェクター、実験医学 (羊土社)、27, 1542-1547 (2009).
- Tomoko Kubori, Akihiro Hyakutake and Hiroki Nagai. Legionella
translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct
functions. Mol. Microbiol. 67:1307–1319
(2008). DOI: 10.1111/j.1365-2958.2008.06124.x
- Hiroki Nagai,
Eric D. Cambronne, Jonathan C. Kagan, Juan C. Amor, Richard A. Kahn and Craig
R. Roy. A C-terminal translocation
signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells. Proc.
Natl. Acad. Sci. USA. 102:
826-831 (2005). doi:10.1073/pnas.0406239101
- Juan C. Amor, Jennifer
Swails, Craig R. Roy, Hiroki Nagai, Alyssa Ingmundson, Xiaodong Cheng
and Richard A. Kahn. The structure of
RalF, an ARF guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the
active site. J. Biol. Chem, 280:
1392-1400 (2005). doi:10.1074/jbc.M410820200
- 永井宏樹、病原細菌のIVB型分泌系と宿主細胞内増殖、蛋白質核酸酵素 (共立出版)、50:44-49 (2005)
- 永井宏樹、レジオネラと宿主細胞の相互作用、化学療法の領域 (医薬ジャーナル社)、21:1631-1636
(2005)
- 永井宏樹、レジオネラの感染・増殖の機序を知る—IV型分泌系により宿主細胞中へ輸送されるエフェクターの探索、分子呼吸器病 (先端医学社)、9:490-491
(2005)
- Hiroki Nagai and
Craig R. Roy. Show me the substrates: modulation of host cell function by type IV
secretion systems. Cell. Microbiol. 5: 373-383 (2003). DOI: 10.1046/j.1462-5822.2003.00285.x
- Hiroki Nagai,
Jonathan C. Kagan, Xinjun Zhu, Richard A. Kahn, and Craig R. Roy. A bacterial
guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science
295:
697-682 (2002). DOI: 10.1126/science.1067025
Covered as a research highlight in Nat. Rev. Mol. Cell Biol. 3, 148 (March 2002) | doi:10.1038/nrm771 - 永井宏樹、レジオネラ・ニューモフィラ、細菌毒素ハンドブック(櫻井純、本田武司、小熊恵二編 サイエンスフォーラム)、pp 547-549. (2002).
- Hiroki Nagai and
Craig R. Roy. The DotA protein from Legionella
pneumophila is secreted by a novel process that requires the Dot/Icm
transporter. EMBO J. 20:
5962-5970 (2001). doi: 10.1093/emboj/20.21.5962
- Jorn Coers, Jonathan C. Kagan, Miguelina Matthews, Hiroki
Nagai, Deborah M. Zuckman and Craig R. Roy. Identification of Icm protein
complexes that play distinct roles in the biogenesis of an organelle permissive
for Legionella pneumophila
intracellular growth. Mol. Microbiol. 38: 719-736 (2000). DOI: 10.1046/j.1365-2958.2000.02176.x
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